Eosinophils and Airway Inflammation
نویسندگان
چکیده
منابع مشابه
Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells.
The capacity of airway eosinophils, potentially pertinent to allergic diseases of the upper and lower airways, to function as professional APCs, those specifically able to elicit responses from unprimed, Ag-naive CD4(+) T cells has been uncertain. We investigated whether airway eosinophils are capable of initiating naive T cell responses in vivo. Eosinophils, isolated free of other APCs from th...
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Eosinophils are potent effector cells implicated in allergic responses and helminth infections. Responding to stimuli, they release their granule-derived cytotoxic proteins and are involved in inflammatory processes. However, under homeostatic conditions, eosinophils are abundantly present in the intestine and are constantly in contact with the gut microbiota and maintain the balance of immune ...
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Introduction Eosinophils are continually targeted in allergic airway inflammatory disease therapies. The presence of their granules in airway tissues remains unexplained, yet implies the involvement of necrosis. The latter’s definition has evolved into a highly regulated and distinct signalling pathway leading to physiological inflammation, known as necroptosis. Even though necroptosis is a rec...
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COPD is a significant cause of morbidity and mortality. In some patients with COPD, eosinophils contribute to inflammation that promotes airway obstruction; approximately a third of stable COPD patients have evidence of eosinophilic inflammation. Although the eosinophil threshold associated with clinical relevance in patients with COPD is currently subject to debate, eosinophil counts hold pote...
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ژورنال
عنوان ژورنال: Journal of Genetic Syndromes & Gene Therapy
سال: 2014
ISSN: 2157-7412
DOI: 10.4172/2157-7412.1000220